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Article

c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.

Molecular and cellular biology - 1 Feb 2004

Hong Li, Munugalavadla Veerendra, Kapur Reuben

Abstract excerpt

A critical issue in understanding receptor tyrosine kinase signaling is the individual contribution of diverse signaling pathways in regulating cellular growth, survival, and migration. We generated a functionally and biochemically inert c-Kit receptor that lacked the binding sites for seven early signaling pathways. Restoring the Src family kinase (SFK) binding sites in the mutated c-Kit receptor restored...

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Identifiers

PMID: 14729982
DOI: 10.1128/MCB.24.3.1401-1410.2004
PMCID: PMC321438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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