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Article

Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells.

Blood - 1 Apr 2003

Hermans Mirjam H A, van de Geijn Gert-Jan, Antonissen Claudia, Gits Judith, van Leeuwen Daphne, Ward Alister C, Touw Ivo P

Abstract excerpt

Granulocyte colony-stimulating factor (G-CSF) is the major regulator of neutrophil production. Studies in cell lines have established that conserved tyrosines Tyr704, Tyr729, Tyr744, Tyr764 within the cytoplasmic domain of G-CSF receptor (G-CSF-R) contribute significantly to G-CSF-induced prolife...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinases

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Share to Suppressor of Cytokine Signaling 3 Protein

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Source

Identifiers

PMID: 12468431
DOI: 10.1182/blood-2002-07-2062

Genes

SOCS3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12468431-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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