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Article

Abnormal expression of Toll-like receptor 4 is associated with susceptibility to ethanol-induced gastric mucosal injury in mice.

Digestive diseases and sciences - 1 Oct 2013

Ye Hui-hui, Hua Rong, Yu Le, Wu Ke-jian, Fei Su-juan, Qin Xia, Song Ying, Cao Jun-li, Zhang Yong-mei

Abstract excerpt

BACKGROUND AND AIMS: Toll-like receptor 4 (TLR4) contributes to ethanol-induced gastric mucosal injury. This study aimed to determine its precise role in this pathogenic state and the related signaling pathway. METHODS: Ethanol-induced gastric mucosal injury models were generated in TLR4(-/-) mice (C3H/HeJ: point mutation; C57BL/10ScNJ: gene deletion), their respective TLR4(+/+) wild-type counterparts, and...

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Source

Identifiers

PMID: 23744365
DOI: 10.1007/s10620-013-2727-5

Genes

TLR4
HMGB1
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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