Article

A Triple-Hit Alcoholic Liver Disease Model Linking High-Fat Diet, Endotoxins, and Neo-Antigen Formation

2025-11-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Existing rodent models of alcoholic liver disease (ALD) often fail to replicate its full clinical progression—from steatosis to alcoholic hepatitis and ultimately cirrhosis—and overlook key metabolic contributors. Clinically, high-fat diets and gut-derived endotoxins (from enteric dysbiosis) act as additional “hits” that exacerbate alcohol-induced liver injury. Moreover, alc...

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Literature Corpus work: 87d176a0-1457-5b3c-a76f-d172f2abcaca
DOI: 10.1101/2025.11.10.687007

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