Article
Role of acute ethanol exposure and TLR4 in early events of sepsis in a mouse model.
Alcohol (Fayetteville, N.Y.) - 1 Dec 2011
Bhatty Minny, Jan Basit L, Tan Wei, Pruett Stephen B, Nanduri Bindu
Abstract excerpt
Sepsis is a major cause of death worldwide. The associated risks and mortality are known to significantly increase on exposure to alcohol (chronic or acute). The underlying mechanisms of the association of acute ethanol ingestion and poor prognosis of sepsis are largely unknown. The study described here was designed to determine in detail the role of ethanol and TLR4 in the pathogenesis of the sepsis syndrome....
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