Article
Large-scale analysis of mutations in RET exon 16 in sporadic medullary thyroid carcinomas in Japan.
Japanese journal of cancer research : Gann - 1 Jun 2001
Takano T, Miyauchi A, Yoshida H, Hasegawa Y, Kuma K, Amino N
Abstract excerpt
Germline mutations in the RET proto-oncogene are the cause of multiple endocrine neoplasia type 2 (MEN 2A and 2B) and familial medullary thyroid carcinoma (FMTC). Some cases of sporadic medullary thyroid carcinoma (MTC) have also been reported to have mutations in the RET gene. However, two previous reports have given discrepant results on the frequency of the mutations in RET in sporadic MTCs in Japan. To...
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