Article
[Analysis of mutations in the RET proto-oncogene in patients with medullary thyroid tumor].
Genetika - 1 Jun 2003
Amosenko F A, Brzhezovskiĭ V Zh, Liubchenko L N, Shabanov M A, Kozlova V M, Vanushko V E, Kazubskaia T P, Gar'kavtseva R F, Kalinin V N
Abstract excerpt
The spectrum of mutations of the RET protooncogene was analyzed in Russian patients with inherited or sporadic medullary thyroid carcinoma (MTC). Four RET exons (11, 13, 15, and 16) were subjected to molecular analysis, and mutations were revealed and identified in 47.4% (9/19) patients with sporadic MTC. In total, six mutations (including three new ones) were observed. The most common mutation affected codon 918...
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