Article
Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas.
British journal of cancer - 2 Jun 2009
Moura M M, Cavaco B M, Pinto A E, Domingues R, Santos J R, Cid M O, Bugalho M J, Leite V
Abstract excerpt
Screening of REarranged during Transfection (RET) gene mutations has been carried out in different series of sporadic medullary thyroid carcinomas (MTC). RET-positive tumours seem to be associated to a worse clinical outcome. However, the correlation between the type of RET mutation and the patients' clinicopathological data has not been evaluated yet. We analysed RET exons 5, 8, 10-16 in fifty-one sporadic MTC,...
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