Article
Detection of a K-ras mutation in urine of patients with colorectal cancer.
Cancer biomarkers : section A of Disease markers - 1 Jan 2005
Su Ying-Hsiu, Wang Mengjun, Aiamkitsumrit Benjamas, Brenner Dean E, Block Timothy M
Abstract excerpt
We previously demonstrated that human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation, which may be useful in the detection of colorectal cancer. In this report we have determined the stability of DNA in urine and have found that the half-life time interval of this small, fragmented DNA is at least 4 hours post collection. We further compared, in a blinded study, the...
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