Article
Fluoroquinolone resistance is a poor surrogate marker for type II topoisomerase mutations in clinical isolates of Streptococcus pneumoniae.
Journal of clinical microbiology - 1 Jul 2001
Millichap J J, Pestova E, Siddiqui F, Noskin G A, Peterson L R
Abstract excerpt
The association between fluoroquinolone susceptibility and DNA mutations coding for amino acid substitutions in the quinolone resistance-determining region was assessed with 44 clinical isolates of Streptococcus pneumoniae. Twenty-three strains bore at least one amino acid substitution. Only seven strains with mutations were suggested by diminished susceptibility to ciprofloxacin (MIC, > or =2 microg/ml).
Topics
- Amino Acid Substitution
- Anti-Infective Agents
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Genetic Markers
- Humans
- Microbial Sensitivity Tests
- Mutation
- Pneumococcal Infections