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Topoisomerase II and IV quinolone resistance-determining regions in Stenotrophomonas maltophilia clinical isolates with different levels of quinolone susceptibility.

Antimicrobial agents and chemotherapy - 1 Mar 2002

Valdezate Sylvia, Vindel Ana, Echeita Aurora, Baquero Fernando, Cantó Rafael

Abstract excerpt

The quinolone resistance-determining regions (QRDRs) of topoisomerase II and IV genes from Stenotrophomonas maltophilia ATCC 13637 were sequenced and compared with the corresponding regions of 32 unrelated S. maltophilia clinical strains for which ciprofloxacin MICs ranged from 0.1 to 64 microg/ml. GyrA (Leu-55 to Gln-155, Escherichia coli numbering), GyrB (Met-391 to Phe-513), ParC (Ile-34 to Arg-124), and ParE...

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Identifiers

PMID: 11850246
DOI: 10.1128/AAC.46.3.665-671.2002
PMCID: PMC127482

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Topoisomerase II and IV quinolone resistance-determining regions in Stenotrophomonas maltophilia clinical isolates with different levels of quinolone susceptibility.PMID 11850246Read ↗

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