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Article

DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Nov 1998

Pan X S, Fisher L M

Abstract excerpt

We examined the response of Streptococcus pneumoniae 7785 to clinafloxacin, a novel C-8-substituted fluoroquinolone which is being developed as an antipneumococcal agent. Clinafloxacin was highly active against S. pneumoniae 7785 (MIC, 0.125 microg/ml), and neither gyrA nor parC quinolone resistance mutations alone had much effect on this activity. A combination of both mutations was needed to register...

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Source

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Identifiers

PMID: 9797208
DOI: 10.1128/AAC.42.11.2810
PMCID: PMC105948

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Source receipt: pubmed, retrieved 7 Sept 2026.

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