Article
Genetic analyses of mutations contributing to fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Dec 2001
Weigel L M, Anderson G J, Facklam R R, Tenover F C
Abstract excerpt
Twenty-one clinical isolates of Streptococcus pneumoniae showing reduced susceptibility or resistance to fluoroquinolones were characterized by serotype, antimicrobial susceptibility, and genetic analyses of the quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC, and parE. Five...
Topics
- Anti-Infective Agents
- Chromosomes, Bacterial
- DNA Gyrase
- DNA Topoisomerase IV
- DNA, Bacterial
- Drug Resistance, Microbial
- Fluoroquinolones
- Genes, Bacterial
- Humans
- Microbial Sensitivity Tests
- Mutation
- Pneumococcal Infections
- Reverse Transcriptase Polymerase Chain Reaction
- Streptococcus pneumoniae
- Transformation, Genetic