Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The TEL-AML1 fusion accompanied by loss of the untranslocated TEL allele in B-precursor acute lymphoblastic leukaemia of childhood.

Leukemia & lymphoma - 1 Dec 2000

Kempski H M, Sturt N T

Abstract excerpt

The TEL-AML1 fusion which results from the t(12;21) rearrangement in childhood B-precursor acute lymphoblastic leukaemia (B-precursor ALL) is often accompanied by loss of the untranslocated TEL allele. From 32/109 children with B-precursor ALL screened for these abnormalities, we found evidence for del 12p, including the loss of the untranslocated TEL allele, to be the secondary event to take place in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Core Binding Factor Alpha 2 Subunit
Share to ETS Translocation Variant 6 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Oncogene Proteins, Fusion

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-ets

Share to Repressor Proteins

Source

Identifiers

PMID: 11426627
DOI: 10.3109/10428190009054879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The TEL-AML1 fusion accompanied by loss of the untranslocated TEL allele in B-precursor acute lymphoblastic leukaemia of childhood.PMID 11426627Read ↗

The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell linesSemantic proximity Read ↗

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.Semantic proximity Read ↗

Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.Semantic proximity Read ↗

The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusionSemantic proximity Read ↗

Incidence of TEL/AML1 Fusion Gene Analyzed Consecutively in Children With Acute Lymphoblastic Leukemia in RelapseSemantic proximity Read ↗

Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.Semantic proximity Read ↗

Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia withTEL/AML1 gene fusionSemantic proximity Read ↗

Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case.Semantic proximity Read ↗

Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.Semantic proximity Read ↗

Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia.Semantic proximity Read ↗

Incidence and Clinical Relevance of TEL/AML1 Fusion Genes in Children With Acute Lymphoblastic Leukemia Enrolled in the German and Italian Multicenter Therapy TrialsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.