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Article

Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia withTEL/AML1 gene fusion

1 Mar 1999

Abstract excerpt

TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence in situ hybridization (FISH) allowed us to identify chromosome anomalies in addition to the already existing...

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PMID: 10451708
DOI: 10.1002/(sici)1098-2264(199903)24:3<272::aid-gcc13>3.0.co;2-u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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