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Article

Incidence of TEL/AML1 Fusion Gene Analyzed Consecutively in Children With Acute Lymphoblastic Leukemia in Relapse

15 Dec 1997

Abstract excerpt

The translocation t(12; 21)(p13; q22) is difficult to detect by classic cytogenetics. However, using fluorescence in situ hybridization (FISH) and by screening for the TEL/AML1 rearrangement by the polymerase chain reaction (PCR), it has been demonstrated to be the most frequent known structural chromosomal abnormality in childhood acute lymphoblastic leukemia (ALL). It is closely correlated with a B-cell...

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PMID: 9389711
DOI: 10.1182/blood.v90.12.4933

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Incidence of TEL/AML1 Fusion Gene Analyzed Consecutively in Children With Acute Lymphoblastic Leukemia in RelapsePMID 9389711Read ↗

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The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusionSemantic proximity Read ↗

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