Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.

doi:10.1038/sj.leu.2400571

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Article

Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.

Leukemia - 1 Mar 1997

Uphoff C C, MacLeod R A, Denkmann S A, Golub T R, Borkhardt A, Janssen J W, Drexler H G

Abstract excerpt

The recurrent (12;21)(p13;q22) translocation fuses the two genes TEL and AML1 that have previously been cloned from translocation breakpoints in myeloid leukemias. Using mainly reverse transcriptase-polymerase chain reaction (RT-PCR), the TEL-AML1 chimeric transcript has been observed in 22-27% o...

Topics

Adolescent
Adult
Child
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 21
Female
Gene Rearrangement
Genotype
Humans
Immunophenotyping
Infant
Karyotyping
Leukemia, B-Cell
Male
Middle Aged
Neoplasm Proteins
Oncogene Proteins, Fusion
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 9067587
DOI: 10.1038/sj.leu.2400571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9067587-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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