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Article

The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion

15 Jun 1995

Abstract excerpt

Analysis of a growing number of chromosomal translocations in human tumors have shown that they frequently result in gene fusions encoding chimeric proteins. We have characterized the recurrent t(12;21)(p12;q22) translocation present in human B-lineage acute leukemias. This translocation fused two genes, tel and AML1, that have previously been described in chromosomal translocations specific for myeloid...

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PMID: 7780150
DOI: 10.1182/blood.v85.12.3662.bloodjournal85123662

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Related research

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The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusionPMID 7780150Read ↗

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.Semantic proximity Read ↗

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The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methodsSemantic proximity Read ↗

Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemiaSemantic proximity Read ↗

Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.Semantic proximity Read ↗

Incidence and Clinical Relevance of TEL/AML1 Fusion Genes in Children With Acute Lymphoblastic Leukemia Enrolled in the German and Italian Multicenter Therapy TrialsSemantic proximity Read ↗

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The TEL-AML1 fusion accompanied by loss of the untranslocated TEL allele in B-precursor acute lymphoblastic leukaemia of childhood.Semantic proximity Read ↗

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