Article
Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case.
Cancer research - 1 Jun 1996
Wlodarska I, Baens M, Peeters P, Aerssens J, Mecucci C, Brock P, Marynen P, Van den Berghe H
Abstract excerpt
Recently, a new recurrent t(12;21)(pl3;q22) has been identified in a B-cell lineage childhood acute lymphoblastic leukemia (ALL). The translocation results in a fusion of two known genes, ETV6/TEL (12p13) and AML1 (21q22), previously shown to be involved in the pathogenesis of myeloid disorders....
Topics
- Adolescent
- Alleles
- Base Sequence
- Chromosome Aberrations
- Chromosome Banding
- Chromosome Deletion
- Chromosome Disorders
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 21
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Primers
- Female
- Gene Expression
- Humans
- In Situ Hybridization, Fluorescence
- Molecular Sequence Data
- Precursor Cell Lymphoblastic Leukemia-Lymphoma