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Article

Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.

Genes, chromosomes & cancer - 1 Feb 2013

Al-Shehhi Halima, Konn Zoe J, Schwab Claire J, Erhorn Amy, Barber Kerry E, Wright Sarah L, Gabriel Alem S, Harrison Christine J, Moorman Anthony V

Abstract excerpt

ETV6-RUNX1 fusion [t(12;21)(p13;q22)] occurs in 25% of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and is associated with a favorable outcome. Additional abnormalities involving der(21)t(12;21) and nonrearranged chromosome 12 are well characterized but aberrations involving the der(12)t(12;21) have rarely been described. Herein, we describe two novel abnormalities affecting the...

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Identifiers

PMID: 23077088
DOI: 10.1002/gcc.22021

Genes

ETV6
RUNX1
DUSP16
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.PMID 23077088Read ↗

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Involvement of der(12)t(12;21)(p13;q22) and as well as additional rearrangements of chromosome 12 homolog in ETV6/RUNX1-positive acute lymphoblastic leukemia.Semantic proximity Read ↗

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