Article
Genetic and environmental contributions to platelet aggregation: the Framingham heart study.
Circulation - 26 Jun 2001
O'Donnell C J, Larson M G, Feng D, Sutherland P A, Lindpaintner K, Myers R H, D'Agostino R A, Levy D, Tofler G H
Abstract excerpt
BACKGROUND: Platelet aggregation plays an important role in arterial thrombosis in coronary heart disease, stroke, and peripheral arterial disease. However, the contribution of genetic versus environmental influences on interindividual variation in platelet aggregability is poorly characterized. METHODS AND RESULTS: We studied the heritability of platelet aggregation responses in 2413 participants in the...
Topics
- Adenosine Diphosphate
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Binding Sites
- Collagen
- DNA
- Deoxyribonuclease HindIII
- Epinephrine
- Female
- Fibrinogen