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Article

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations.

The EMBO journal - 1 Apr 1998

Brachmann R K, Yu K, Eby Y, Pavletich N P, Boeke J D

Abstract excerpt

Several lines of evidence suggest that the presence of the wild-type tumor suppressor gene p53 in human cancers correlates well with successful anti-cancer therapy. Restoration of wild-type p53 function to cancer cells that have lost it might therefore improve treatment outcomes. Using a systemat...

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Identifiers

PMID: 9524109
DOI: 10.1093/emboj/17.7.1847
PMCID: PMC1170532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9524109-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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