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Article

Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2001

Marra G, D'Atri S, Corti C, Bonmassar L, Cattaruzza M S, Schweizer P, Heinimann K, Bartosova Z, Nyström-Lahti M, Jiricny J

Abstract excerpt

Members of hereditary nonpolyposis colon cancer (HNPCC) families harboring heterozygous germline mutations in the DNA mismatch repair genes hMSH2 or hMLH1 present with tumors generally two to three decades earlier than individuals with nonfamilial sporadic colon cancer. We searched for phenotypic...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Antineoplastic Agents, Alkylating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Source

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Identifiers

PMID: 11416201
DOI: 10.1073/pnas.121136498
PMCID: PMC34640

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11416201-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide.PMID 11416201Read ↗

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Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance.Semantic proximity Read ↗

Mechanisms underlying mismatch repair deficiencies in normal cells.Semantic proximity Read ↗

DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load.Semantic proximity Read ↗

Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.Semantic proximity Read ↗

Biallelic mutation of MSH2 in primary human cells is associated with sensitivity to irradiation and altered RAD51 foci kinetics.Semantic proximity Read ↗

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Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.Semantic proximity Read ↗

Binding of Mismatched Microsatellite DNA Sequences by the Human MSH2 ProteinSemantic proximity Read ↗

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