Article
Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.
Cancer research - 1 Sept 1997
Leadon S A, Avrutskaya A V
Abstract excerpt
Defects in DNA mismatch repair have been associated with both hereditary and sporadic forms of cancer. Recently, it has been shown that human cell lines deficient in mismatch repair were also defective in the transcription-coupled repair (TCR) of UV-induced DNA damage. We examined whether TCR of ionizing radiation-induced DNA damage also requires the genes involved in DNA mismatch repair. Cells defective in the...
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