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Article

Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes.

Cancer research - 1 Nov 2001

Marra G, D'Atri S, Yan H, Perrera C, Cannavo' E, Vogelstein B, Jiricny J

Abstract excerpt

Conversion of diploidy to haploidy is a method that allows the generation of stable murine/human hybrid cell lines carrying selected human chromosomes in only a single copy. In this setting, it is possible to detect genetic mutations with greater sensitivity and reliability than in diploid cells. Using this method, we were able to identify mutations in the human mismatch repair (MMR) gene hMSH2 in hereditary...

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Share to Base Pair Mismatch
Share to Chromosomes, Human, Pair 2
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11691782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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