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Article

Binding of Mismatched Microsatellite DNA Sequences by the Human MSH2 Protein

25 Nov 1994

Abstract excerpt

Alteration of the human mismatch repair gene hMSH2 has been linked to the microsatellite DNA instability found in hereditary nonpolyposis colon cancer and several sporadic cancers. This microsatellite DNA instability is thought to arise from defective repair of DNA replication errors that create insertion-deletion loop-type (IDL) mismatched nucleotides. Here, it is shown that purified hMSH2 protein efficiently...

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PMID: 7973733
DOI: 10.1126/science.7973733

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