Article
Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.
The Journal of biological chemistry - 19 Jul 2013
Zhou Chengwen, Huang Zhiling, Ding Li, Deel M Elizabeth, Arain Fazal M, Murray Clark R, Patel Ronak S, Flanagan Christopher D, Gallagher Martin J
Abstract excerpt
Patients with generalized epilepsy exhibit cerebral cortical disinhibition. Likewise, mutations in the inhibitory ligand-gated ion channels, GABAA receptors (GABAARs), cause generalized epilepsy syndromes in humans. Recently, we demonstrated that heterozygous knock-out (Hetα1KO) of the human epilepsy gene, the GABAAR α1 subunit, produced absence epilepsy in mice. Here, we determined the effects of Hetα1KO on the...
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