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Article

Effects of GABA agonists on body temperature regulation in GABA(B(1))-/- mice.

British journal of pharmacology - 1 Sept 2003

Quéva Christophe, Bremner-Danielsen Marianne, Edlund Anders, Ekstrand A Jonas, Elg Susanne, Erickson Sven, Johansson Thore, Lehmann Anders, Mattsson Jan P

Abstract excerpt

1. Activation of GABA(B) receptors evokes hypothermia in wildtype (GABA(B(1))+/+) but not in GABA(B) receptor knockout (GABA(B(1))-/-) mice. The aim of the present study was to determine the hypothermic and behavioural effects of the putative GABA(B) receptor agonist gamma-hydroxybutyrate (GHB), and of the GABA(A) receptor agonist muscimol. In addition, basal body temperature was determined in GABA(B(1))+/+,...

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Identifiers

PMID: 12970075
DOI: 10.1038/sj.bjp.0705447
PMCID: PMC1574040

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Source receipt: pubmed, retrieved 7 Sept 2026.

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