Article
Floxed allele for conditional inactivation of the GABAB(1) gene.
Genesis (New York, N.Y. : 2000) - 1 Nov 2004
Haller Corinne, Casanova Emilio, Müller Matthias, Vacher Claire-Marie, Vigot Rejan, Doll Thierry, Barbieri Samuel, Gassmann Martin, Bettler Bernhard
Abstract excerpt
GABA(B) receptors are the G-protein-coupled receptors for the neurotransmitter GABA. GABA(B) receptors are broadly expressed in the nervous system. Their complete absence in mice causes premature lethality or--when mice are viable--epilepsy, impaired memory, hyperalgesia, hypothermia, and hyperactivity. A spatially and temporally restricted loss of GABA(B) function would allow addressing how the absence of...
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