The lipopolysaccharide structures of Salmonella enterica serovar Typhimurium and Neisseria gonorrhoeae determine the attachment of human mannose-binding lectin to intact organisms.

Abstract excerpt

Mannose-binding lectin (MBL) is an important component of the innate immune system. It binds to the arrays of sugars commonly presented by microorganisms and activates the complement system independently of antibody. Despite detailed knowledge of the stereochemical basis of MBL binding, relatively little is known about how bacterial surface structures influence binding of the lectin. Using flow cytometry, we have...

Topics

• Carbohydrate Sequence
• Carrier Proteins
• Collectins
• Humans
• In Vitro Techniques
• Lectins
• Lipopolysaccharides
• Mannose
• Molecular Sequence Data
• Mutation
• Neisseria gonorrhoeae