Article
A novel protein involved in heart development in Ambystoma mexicanum is localized in endoplasmic reticulum.
Journal of biomedical science - 1 Nov 2008
Jia P, Zhang C, Huang X P, Poda M, Akbas F, Lemanski S L, Erginel-Unaltuna N, Lemanski L F
Abstract excerpt
The discovery of the naturally occurring cardiac non-function (c) animal strain in Ambystoma mexicanum (axolotl) provides a valuable animal model to study cardiomyocyte differentiation. In homozygous mutant animals (c/c), rhythmic contractions of the embryonic heart are absent due to a lack of organized myofibrils. We have previously cloned a partial sequence of a peptide cDNA (N1) from an...
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