Article
Transgenic Drosophila models of Alzheimer's disease and tauopathies.
Brain structure & function - 1 Mar 2010
Iijima-Ando Kanae, Iijima Koichi
Abstract excerpt
Alzheimer's disease (AD) is the most common form of senile dementia. Aggregation of the amyloid-beta42 peptide (Abeta42) and tau proteins are pathological hallmarks in AD brains. Accumulating evidence suggests that Abeta42 plays a central role in the pathogenesis of AD, and tau acts downstream of Abeta42 as a modulator of the disease progression. Tau pathology is also observed in frontotemporal dementia with...
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