Article
Transgenic zebrafish model of neurodegeneration.
Journal of neuroscience research - 15 Dec 2002
Tomasiewicz Henry G, Flaherty Denise B, Soria J P, Wood John G
Abstract excerpt
In Alzheimer's disease (AD), the microtubule-associated protein, tau, is compromised in its normal association with microtubules and forms into paired helical filaments (PHF) that are the hallmark cytoskeletal pathology of the disease. Several posttranslational modifications of tau including phosphorylation have been implicated in AD pathogenesis. In addition, and importantly, mutations in the genes encoding...
Topics
- Animals
- Animals, Genetically Modified
- Disease Models, Animal
- Humans
- Mutation
- Nerve Degeneration
- Neurodegenerative Diseases
- Neurofibrillary Tangles
- Neurons
- Phosphorylation
- Zebrafish