Article
Specific overexpression of rheumatoid arthritis-associated HLA-DR alleles and presentation of low-affinity peptides.
Arthritis and rheumatism - 1 Jun 2001
Kerlan-Candon S, Louis-Plence P, Wiedemann A, Combe B, Clot J, Eliaou J F, Pinet V
Abstract excerpt
OBJECTIVE: To compare levels of HLA-DR expression in rheumatoid arthritis (RA) patients and healthy controls for whom an ordered expression according to the DR alleles is demonstrated and to test the functional consequences of this expression on peptide presentation. METHODS: Using monoclonal antibodies that recognize different DRB1 alleles, DR molecules were quantitated at the surface of the peripheral blood B...
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