Article
Influence of the HLA-DR beta shared epitope on susceptibility to and clinical expression of rheumatoid arthritis in Chilean patients.
Annals of the rheumatic diseases - 1 Mar 1997
González A, Nicovani S, Massardo L, Aguirre V, Cervilla V, Lanchbury J S, Jacobelli S
Abstract excerpt
OBJECTIVE: To analyse the influence of shared epitope positive HLA-DRB1 alleles (QKRAA or QRRAA)) on rheumatoid arthritis (RA) susceptibility and severity in Chileans, a population that exhibits a weak association with HLA-DR4. METHODS: Prevalence of alleles DRB1*01 and DRB1*04 alleles was determined by polymerase chain reaction amplification and sequence specific oligonucleotide hybridisation in 129 RA patients...
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