Article
Soluble HLA-DR antigen levels in serum correlate with rheumatoid arthritis disease activity and the presence of disease-associated epitopes.
Tissue antigens - 1 Nov 2000
Verbruggen L A, Dumarey N, Van de Velde H, Rebmann V, Flament J, Van Wayenberge C, Grosse-Wilde H, Demanet C
Abstract excerpt
We investigated correlations between soluble HLA-DR (sHLA-DR) molecules and several clinical, biological and genetic parameters associated with rheumatoid arthritis (RA) disease activity. Serum sHLA-DR concentrations were determined in 146 samples from 89 RA patients by an ELISA format, using an antibody combination of mouse and rat monoclonal anti-human HLA-DR antibodies. The mean sHLA-DR serum level in RA...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Animals
- Arthritis, Rheumatoid
- Epitopes, B-Lymphocyte
- Female
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Male
- Mice
- Middle Aged
- Rats