Article
HLA polymorphisms and T cells in rheumatoid arthritis.
International reviews of immunology - 1 Jan 1999
Weyand C M, Goronzy J J
Abstract excerpt
A dense infiltrate of activated T cells, macrophages, and B cells in the synovial membrane is the cardinal pathological feature of rheumatoid arthritis (RA). Frequently, tissue infiltrating cells acquire a morphological organization reminiscent of secondary lymphoid tissue. The composition of the inflammatory lesions, the production of autoantibodies, and the association of disease risk with genes related to the...
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