Article
X-ray induction of microsatellite instability at autosomal loci in human lymphoblastoid WTK1 cells.
Mutation research - 1 Jul 2001
Romney C A, Paulauskis J D, Little J B
Abstract excerpt
Many models of carcinogenesis posit that multiple genetic events are required for a normal cell to become cancerous. As the mutation rate of a single gene is in the range of 10(-8) to 10(-5) per cell division, a central question remains, how does a single cell acquire multiple mutations? One hypothesis, originally articulated by Loeb [10], proposed that some mutations may not be isolated events, but are...
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