Article
Induction of multilocus lesions by UVC-radiation in mouse L5178Y lymphoblasts.
Mutation research - 1 Nov 1991
Evans H H, Ricanati M, Di Salvo C, Horng M F, Menci J
Abstract excerpt
The survival, the mutant frequency and the nature of the DNA alteration responsible for the inactivation of the thymidine kinase (tk) locus were investigated in 5 strains of mouse L5178Y lymphoblasts exposed to UVC radiation. The nature of the DNA alteration was investigated in independent TK-/- mutants using Southern blot analysis. The concomitant loss of galactokinase (GK) activity in homogenates of individual...
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