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Article

Goalpha regulates volatile anesthetic action in Caenorhabditis elegans.

Genetics - 1 Jun 2001

van Swinderen B, Metz L B, Shebester L D, Mendel J E, Sternberg P W, Crowder C M

Abstract excerpt

To identify genes controlling volatile anesthetic (VA) action, we have screened through existing Caenorhabditis elegans mutants and found that strains with a reduction in Go signaling are VA resistant. Loss-of-function mutants of the gene goa-1, which codes for the alpha-subunit of Go, have EC(50)s for the VA isoflurane of 1.7- to 2.4-fold that of wild type. Strains overexpressing egl-10, which codes for an RGS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gi-Go

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Share to Transformation, Genetic

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Identifiers

PMID: 11404329
DOI: 10.1093/genetics/158.2.643
PMCID: PMC1461665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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