Article
The genetics of isoflurane-induced developmental neurotoxicity.
Neurotoxicology and teratology - 1 Jan 2000
Na Hyo-Seok, Brockway Nicole L, Gentry Katherine R, Opheim Elyce, Sedensky Margaret M, Morgan Philip G
Abstract excerpt
INTRODUCTION: Neurotoxicity induced by early developmental exposure to volatile anesthetics is a characteristic of organisms across a wide range of species, extending from the nematode C. elegans to mammals. Prevention of anesthetic-induced neurotoxicity (AIN) will rely upon an understanding of its underlying mechanisms. However, no forward genetic screens have been undertaken to identify the critical pathways...
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