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Article

G protein-coupled receptor kinase function is essential for chemosensation in C. elegans.

Neuron - 27 May 2004

Fukuto Hana S, Ferkey Denise M, Apicella Alfonso J, Lans Hannes, Sharmeen Tahira, Chen Wei, Lefkowitz Robert J, Jansen Gert, Schafer William R, Hart Anne C

Abstract excerpt

G protein-coupled receptors (GPCRs) mediate diverse signaling processes, including olfaction. G protein-coupled receptor kinases (GRKs) are important regulators of G protein signal transduction that specifically phosphorylate activated GPCRs to terminate signaling. Despite previously described roles for GRKs in GPCR signal downregulation, animals lacking C. elegans G protein-coupled receptor kinase-2 (Ce-grk-2)...

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PMID: 15157420
DOI: 10.1016/s0896-6273(04)00252-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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