Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans.

Neuron - 1 Oct 1999

Miller K G, Emerson M D, Rand J B

Abstract excerpt

We investigated the EGL-30 (Gqalpha) pathway in C. elegans by using genetic screens to identify genes that confer phenotypes similar to egl-30 mutants. One such gene, egl-8, encodes a phospholipase Cbeta that is present throughout the nervous system and near intestinal cell junctions. EGL-30 and EGL-8 appear to positively regulate synaptic transmission because reducing their function results in strong aldicarb...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diacylglycerol Kinase
Share to GTP-Binding Protein alpha Subunits, Gi-Go
Share to Helminth Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterotrimeric GTP-Binding Proteins

Share to Nervous System

Share to Phospholipase C beta

Share to Synaptic Transmission

Share to Type C Phospholipases

Source

Open in PubMed Open full text

Identifiers

PMID: 10571227
DOI: 10.1016/s0896-6273(00)80847-8
PMCID: PMC4703424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans.PMID 10571227Read ↗

Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability.Semantic proximity Read ↗

Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle.Semantic proximity Read ↗

The complete family of genes encoding G proteins of Caenorhabditis elegans.Semantic proximity Read ↗

A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans.Semantic proximity Read ↗

The G-protein beta-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16.Semantic proximity Read ↗

RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system.Semantic proximity Read ↗

EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.Semantic proximity Read ↗

Goalpha regulates volatile anesthetic action in Caenorhabditis elegans.Semantic proximity Read ↗

Domains, amino acid residues, and new isoforms of Caenorhabditis elegans diacylglycerol kinase 1 (DGK-1) important for terminating diacylglycerol signaling in vivo.Semantic proximity Read ↗

Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans.Semantic proximity Read ↗

Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity.Semantic proximity Read ↗

Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.