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Article

The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.

Biochimica et biophysica acta - 1 Jan 2012

Amin Amit Dipak, Dimova Dessislava K, Ferreira Monica E, Vishnoi Nidhi, Hancock Leandria C, Osley Mary Ann, Prochasson Philippe

Abstract excerpt

The histone genes are an important group of cell cycle regulated genes whose transcription is activated during the G1/S transition and repressed in early G1, late S, and G2/M. The HIR complex, comprised of Hir1, Hir2, Hir3 and Hpc2, regulates three of the four histone gene loci. While relief of repression at the G1/S boundary involves the HIR complex, as well as other cofactors, the mechanism by which this...

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PMID: 21978826
DOI: 10.1016/j.bbagrm.2011.09.003
PMCID: PMC3249481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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