Article
The hippocampus plays an important role in eyeblink conditioning with a short trace interval in glutamate receptor subunit delta 2 mutant mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 2003
Takatsuki Kanako, Kawahara Shigenori, Kotani Sadaharu, Fukunaga Satoshi, Mori Hisashi, Mishina Masayoshi, Kirino Yutaka
Abstract excerpt
Mutant mice lacking the glutamate receptor subunit delta2 exhibit changes in the structure and function of the cerebellar cortex. The most prominent functional feature is a deficiency in the long-term depression (LTD) at parallel fiber-Purkinje cell synapses. These mutant mice exhibit severe impairment during delay eyeblink conditioning but learn normally during trace eyeblink conditioning without the cerebellar...
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