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Article

Reassessment of long-term depression in cerebellar Purkinje cells in mice carrying mutated GluA2 C terminus.

Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2016

Yamaguchi Kazuhiko, Itohara Shigeyoshi, Ito Masao

Abstract excerpt

Long-term depression (LTD) of synaptic transmission from parallel fibers (PFs) to a Purkinje cell (PC) in the cerebellum has been considered to be a core mechanism of motor learning. Recently, however, discrepancies between LTD and motor learning have been reported in mice with a mutation that targeted the expression of PF-PC LTD by blocking AMPA-subtype glutamate receptor internalization regulated via the...

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Identifiers

PMID: 27551099
DOI: 10.1073/pnas.1609957113
PMCID: PMC5018784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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