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Article

Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I.

The Journal of cell biology - 27 Oct 2003

Feil Robert, Hartmann Jana, Luo Chongde, Wolfsgruber Wiebke, Schilling Karl, Feil Susanne, Barski Jaroslaw J, Meyer Michael, Konnerth Arthur, De Zeeuw Chris I, Hofmann Franz

Abstract excerpt

The molecular basis for cerebellar plasticity and motor learning remains controversial. Cerebellar Purkinje cells (PCs) contain a high concentration of cGMP-dependent protein kinase type I (cGKI). To investigate the function of cGKI in long-term depression (LTD) and cerebellar learning, we have g...

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Share to Adaptation, Physiological
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14568994
DOI: 10.1083/jcb.200306148
PMCID: PMC2173527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14568994-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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