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Article

Lgr4 protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar parallel fiber-Purkinje cell synapses.

The Journal of biological chemistry - 19 Sept 2014

Guan Xin, Duan Yanhong, Zeng Qingwen, Pan Hongjie, Qian Yu, Li Dali, Cao Xiaohua, Liu Mingyao

Abstract excerpt

Cerebellar dysfunction causes ataxia characterized by loss of balance and coordination. Until now, the molecular and neuronal mechanisms of several types of inherited cerebellar ataxia have not been completely clarified. Here, we report that leucine-rich G protein-coupled receptor 4 (Lgr4/Gpr48) is highly expressed in Purkinje cells (PCs) in the cerebellum. Deficiency of Lgr4 leads to an ataxia-like phenotype in...

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Identifiers

PMID: 25063812
DOI: 10.1074/jbc.M114.564138
PMCID: PMC4176234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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