Article
Homozygous deletions at 8p22 and 8p21 in prostate cancer implicate these regions as the sites for candidate tumor suppressor genes.
Oncogene - 16 Nov 1995
Kagan J, Stein J, Babaian R J, Joe Y S, Pisters L L, Glassman A B, von Eschenbach A C, Troncoso P
Abstract excerpt
Frequent loss of an allele at specific chromosomal regions implicates these regions as sites of tumor suppressor genes (TSG) that become inactivated during tumor progression. We have studied chromosome 8p allele losses in 32 primary human prostate carcinomas with 16 polymorphic microsatellite sequences. Overall, 22 of 32 (69%) informative specimens showed loss of allele in at least one locus. The most frequent...
Topics
- Alleles
- Binding Sites
- Chromosomes, Human, Pair 8
- Gene Deletion
- Genes, Tumor Suppressor
- Homozygote
- Humans
- Male
- Prostatic Neoplasms