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Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae

19 Nov 1999

Abstract excerpt

The human adenovirus serotype 5 (Ad5) is used widely for applications in human gene therapy. Cellular attachment of Ad5 is mediated by binding of the carboxyl-terminal knob of its fiber coat protein to the Coxsackie adenovirus receptor (CAR) protein. However, Ad5 binding to CAR hampers the development of adenovirus vectors capable of specifically targeting (diseased) tissues or organs. Through sequence analysis...

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PMID: 10567265
DOI: 10.1126/science.286.5444.1568

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Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing AdenoviridaePMID 10567265Read ↗

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